Informasi Detil Paper |
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| Judul: | Peranan Biomarker Untuk Pendeteksian Karsinoma Paru : Kaitannya Dengan Aktivitas Proliferasi Sel Khususnya AgNORs (Agryrophylic Nuclear Organizer Region) Dan Gen Cellular MYC (c-Myc) Serta Apoptosis Sel Khususnya Anti-Onkogen p53 Dan Gen Bcl-2 |
| Penulis: | Theopilus Wilhelmus Watuguly || email: info@mx.unpatti.ac.id |
| Jurnal: | Molucca Medica Vol. 1 no. 1 - hal. 25-33 Tahun 2008 [ Kedokteran ] |
| Keywords: | biomarker, lung carcinoma, proliferation and apoptosis cell, p53.AgNORs, Bcl-2, c-Myc. |
| Abstract: | Lung cancer is the leading cause of cancer deaths in developed countries. The poor prognosis associated with this disease is closely related to the fact that most lung cancer patients are not identified until their malignancy has reached an advanced stage. The controller of homeostasis tissue is very complex and many factors give contribution to growth and development of tumor. Detection of biomoleculer toward the lung cancer can apply marker p53, AgNORs, c-Myc and Bcl-2 also some other biomarker. Recent has been recognized trouble in homeostasis mechanism, what arranges proliferation of cell and cell death (apoptosis), contribution can toward development and lung cancer growth rate. In fact, apoptosis has the role of core in limiting population expansion of tumor cell in the early ofcarcinogenesis process, and inhibition apotosishas proven plays important role in genesis from lung cancer. Neoplastic cell progresifity is shadow of nature and cell conduct which has turned into maligna. Cancer cell growing are abundant happened proliferation activinitiation is a real important change at initial stadium from promotion of tumor which is label typical of lesion precancer. |
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