Informasi Detil Paper

Judul: Antidiabetic And Antioxidant Activity of Endophytic Fungi From Sirih Hitam Plant (Piper Betel L)
Penulis: Edward J. Dompeipen  || email:
Jurnal: Prosiding FMIPA 2016 Vol. 1 no. 1 - hal. 49-57 Tahun 2016  [ Prosiding ]
Keywords:  Piper betel L, α-glucosidase, 2,2-difenil-1-pikrilhidrazil, antidiabetic, antioxidant.
Abstract: Diabetes Mellitus is a degenerative disease characterized by hyperglycemia due to the bodies absolute insulin and relative insulin deficiency. The study was aimed to isolate endophytic fungi from stem of Sirih hitam (Piper betel L) plant was active as antidiabetic and antioxidant. Antidiabetic activity conducted by using the α-glucosidase inhibitory and antioxidant activity using free radical reduction method with reagent 2.2-diphenyl-1- picrylhydrazyl (DPPH). Isolation of microbes conducted in the media Corn Meal Malt Agar (CMMA) and Potato Dextrose Agar (PDA) and obtained 9 isolates of fungus.Inhibitory activity against α-glucosidase to extract the filtrate and biomass of the isolates A.Ps.1F (55.45 and 80.22%), A.Ps.4F(57.40 and 51.48%), A.Ps.5F (70.92 and 70.92%), and B.Ps.1F (62.23 and 53.51%).) thus has potentials an antidiabetic activity. A.Ps.1F were the only isolates active as antioxidants with IC 50 of 95.09 ppm.
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