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Judul: | α-Glucosidase Inhibition Activity of Several Fatty Acid Compounds |
Penulis: | Edward J. Dompeipen & Maria A. Leha || email: mia.biam@gmail.com |
Jurnal: | Prosiding FMIPA 2015 Vol. 1 no. 1 - hal. 63-69 Tahun 2015 [ MIPA ] |
Keywords: | Inhibition activity, α-glucosidase, saturated fatty acid, unsaturated fatty acid |
Abstract: | The research about inhibition activity for α-glucosidase of some fatty acid compounds have been done. Saturated fatty acid such as lauric acid (12:0), palmitic acid(16:0), stearic acid (18:0), and unsaturated fatty acid like oleic acid (18:1), linoleic acid (18:2), a-linoleic acid, and compounds mixture which contain fatty acid such as Virgin Coconut Oil (VCO), olive oil and shark liver oil. The method used to in vitro test antidiabetic activity is inhibition toward α- glucosidase. Acarbose is used as positive control. Inhibition activity toward α-glucosidase of fatty acid compounds: lauric acid (50.22%), palmitic acid (49.39%), stearic acid (41.30%), oleic acid (87.17%), linoleic acid (89.24%), a-linoleic acid (89.55%), compounds mixture which contain fatty acid: Virgin Coconut Oil (VCO) (55.42%), olive oil (24.55%) and shark liver oil (61,60%). It can be concluded that the increase number of double bonds of fatty acid can lead the increased of antidiabetic activity and bond extension of saturated fatty acid can be able to reduce antidiabetic activity and also inhibition activity of single fatty acid compound has no effect toward mixture inhibition, but it highly depend on interaction of each components of mixture itself. |
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