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Judul: Effect Of Ethanol Leaf Extract Gambir Laut (Clerodendrum inerme L. Gaertn) Malformations On Motion To External Equipment Fetal Development Mice (Mus musculus)
Penulis: Chomsa Dintasari Umi Baszary, Maria Nindatu & Tony Marchel Lolonlun  || email:
Jurnal: Prosiding FMIPA 2015 Vol. 1 no. 1 - hal. 135-139 Tahun 2015  [ MIPA ]
Keywords:  Gambir Laut (Clerodendrum inerme L. Gaertn), Ethanol Extract malformations, extrimity.
Abstract: Gambir laut (Clerodendrum inerme L. Gaertn) is one of the plants that contain several chemical compounds such as flavonoids, saponins, tannins, triterpenoids and glycosides in which the group of chemical compounds can potentially affect the fetal development of mice (Mus musculus). This study aimed to determine the effect of ethanol extract of leaves of gambir laut (Clerodendrum inerme L. Gaertn) against external malformations in fetal development locomotor mice (Mus musculus). Pregnant mice were divided into four treatment groups. Each group was given the extract at a dose of 0, 350, 700 and 1400 mg / g BW on gestation day 6 to 15 and on day 18 mice were dissected parent to external malformations observed in locomotor of the fetus. The results showed the ethanol extract of the leaves of Gambir Laut increase the number of external malformations in locomotor from fetal mice. For the upper extremities percentage of external malformations appear at a dose of 350 mg/g of 22.99%, a dose of 700 mg/g of 77.78% and a dose of 1400 mg/g of 83.33%. For the lower extremities percentage of external malformations that appear on the dose of 350 mg/g of 30.54%, a dose of 700 mg/g of 81.48% and a dose of 1400 mg/g BB of 76.67%.
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